India were bowled out for 76 while chasing 202 as England secured a 125-run victory in the third T20I at Nottingham on Tuesday.
India folded in 11.4 overs after England posted 201 for seven. Phil Salt scored 70 and Sam Curran remained unbeaten on 41.
Josh Tongue took four wickets for 28 runs and Jofra Archer claimed three for 29. Prince Yadav returned figures of two for 30 for India.
The result gave England an unassailable 2-0 lead in the five-match series. Shreyas Iyer stayed winless as India captain.
It was India's second-lowest total in T20I history and their worst defeat by runs margin.