The Oklahoma City Thunder will host the Los Angeles Lakers on Wednesday, November 12, 2025, in a key Western Conference matchup at Paycom Center. The defending champions enter with an 11-1 record, while the Lakers sit at 8-3 without LeBron James. Tipoff is set for 9:30 p.m. ET, with the Thunder favored by 8 points and the over/under at 229.5.
The Oklahoma City Thunder, fresh off their first NBA title since 1979, continue their dominant start to the 2025-26 season with an 11-1 record. They recently defeated the Golden State Warriors 126-102 on Tuesday, marking their sixth straight win by at least 14 points. Reigning MVP Shai Gilgeous-Alexander is averaging 32.8 points and 6.4 assists per game, while Chet Holmgren contributes 19.6 points and 8.9 rebounds. The Thunder are 5-0 at home and 7-5 against the spread overall.
The Los Angeles Lakers hold an 8-3 record and boast a strong 8-3 mark against the spread, but they face challenges without LeBron James, who remains sidelined by sciatica. Luka Doncic has been a standout, scoring 38 points in their recent 121-111 win over the Charlotte Hornets. The Lakers' games have gone over the total nine times in 11 tries this season.
Odds list the Thunder as 8-point home favorites with a money line of -325, while the Lakers are +259 underdogs. The over/under is set at 229.5 points, a total that has hit in four of Oklahoma City's five home games. Injuries plague the Thunder as well, with Aaron Wiggins (adductor) and Jalen Williams (wrist) among six players ruled out on the second night of a back-to-back.
SportsLine's Projection Model, which simulates games 10,000 times, predicts the over hits in nearly 60% of simulations and favors one side of the spread over 60% of the time. This matchup highlights two Western Conference powers early in the season.
