Transplants
Texas A&M study links higher glass-transition temperatures to fewer cracks in vitrified tissues
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Researchers at Texas A&M University report that raising the glass-transition temperature of aqueous vitrification solutions can reduce thermal-stress cracking—one of the key barriers to long-term cryopreservation of larger tissues and, eventually, transplant organs.
A study published on Monday in Nature Microbiology confirms long-term HIV remission in the «Oslo patient», a 62-year-old man treated for myelodysplasia via stem cell transplant from his brother carrying the CCR5 Delta 32 mutation. He has been off antiretrovirals for four years with no detectable virus. This brings the total to ten patients deemed cured this way.
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Brazil's Fiocruz, through its Farmanguinhos unit, has begun fully domestic production of tacrolimus, an immunosuppressant to prevent organ transplant rejection. The milestone stems from a Product Development Partnership (PDP) with Brazilian firm Libbs, which acquired manufacturing technology from India's Biocon. Farmanguinhos now becomes the sole supplier to the SUS public health system.