Serena Williams is set to feature in a Super Bowl commercial promoting the telehealth firm Ro and its GLP-1 weight loss medication Zepbound. The 44-year-old tennis legend discusses her body transformation, having lost up to 15.4kg since starting the treatment. The ad comes amid ongoing speculation about a potential return to professional tennis.
Serena Williams, the 23-time Grand Slam champion who retired from tennis in September 2022, will appear in a Super Bowl 60 advertisement airing during the New England Patriots versus Seattle Seahawks game on February 8, 2026. The commercial highlights her partnership with Ro, a company specializing in weight management through GLP-1 medications like Zepbound.
In a preview clip released on Wednesday, Williams shared her experience: "I'm healthier on Ro. I'm on Ro because it works. I lost 34lbs in a year with GLP-1s, my blood sugar? The best it's ever been. My joints? I'm moving better now, I've got more energy for my workouts and for my kids. On Ro, I'm supported, I'm informed and I feel better than I have in years. What does it feel like to be on Ro? Like winning. I'm healthier on Ro."
Williams attributed her initial weight loss of 2st 3lbs (14kg) to the medication, later increasing to 2st 6lbs (15.4kg). She has faced challenges with weight gain since giving birth to her daughter Alexis Olympia in 2017 and second child Adira River in August 2023, despite maintaining a healthy lifestyle. Supporters noticed her transformation in recent months.
The ad appearance follows rumors of a tennis comeback, fueled by Williams re-entering the ITIA's Registered Testing Pool in December 2025, making her eligible for competition after six months of anti-doping availability. Some reports tipped an announcement during the Super Bowl, but the commercial focuses on health rather than tennis.
Williams has repeatedly downplayed return speculation. In a January 28, 2026, Today show interview, she responded to questions about the testing pool with surprise: "I mean, really? Are you asking this on the Today show? Oh my gosh." She added, "I’m just having fun and enjoying my life right now."
Earlier, on social media, she stated: "Omg, y’all, I’m NOT coming back. This wildfire is crazy." Her sister Venus Williams noted, "Hey, I can only speak for myself, and all I know is I can’t get her on the court. She doesn’t practice, so it seems very unlikely."
Tennis great Billie Jean King offered a balanced view: "I think she wants to try to play again. But I think she’s also very bright and very smart that she knows she’s not going to be No 1 again. But if you love to play, why not?"
Recently, American player Alycia Parks practiced with Williams and praised her fitness: "She is in great shape. So I think she would kill it on tour." Despite such optimism, Williams' Super Bowl spot emphasizes personal health over athletic revival, leaving fans to speculate on her future.
