Study links GLP-1 drugs to modest hair loss risk

A new analysis of patient records shows that adults with type 2 diabetes who take GLP-1 receptor agonists face a higher rate of alopecia than those on other common diabetes medications.

The study, published July 22, 2026, in The BMJ, examined electronic health records from Penn Medicine covering patients treated from January 2019 to September 2024.

After adjustments for age, sex, body mass index and other factors, GLP-1 users showed a 37 percent higher risk of alopecia compared with SGLT-2 inhibitor users and a 68 percent higher risk compared with DPP-4 inhibitor users.

The increased risk was confined to non-scarring alopecia, a form that may allow hair to regrow. Absolute rates remained low at roughly 6 to 7 cases per 1,000 person-years.

Researchers noted that rapid weight loss associated with the drugs could contribute to the effect through nutrient deficiencies or hormonal shifts, though the study could not confirm causation.

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A large review of cardiovascular outcome trials found that people taking GLP-1 receptor agonists—drugs that include semaglutide (sold as Ozempic)—had a lower risk of major heart-related events than those given placebo. The analysis pooled results from 11 trials involving more than 90,000 participants, with an average follow-up of nearly three years, and reported benefits across patient subgroups including those with and without diabetes.

A new experimental oral medication called elecoglipron improved blood sugar control and promoted weight loss in adults with type 2 diabetes during a phase 2b trial. Results from the SOLSTICE study were presented at the American Diabetes Association's Scientific Sessions and published in The Lancet.

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A year-long observational study in Japan suggests that people with type 2 diabetes who tend to overeat in response to tempting food cues such as sight and smell may see greater weight loss—and possibly better blood-sugar improvement—after starting GLP-1 receptor agonists, while those with primarily emotional eating patterns show less consistent links to long-term outcomes.

Researchers say genetic variants in the PAM gene may help explain why some people with Type 2 diabetes get less blood-sugar benefit from GLP-1 receptor agonist drugs such as Ozempic, a phenomenon they describe as “GLP-1 resistance.”

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A study from Rutgers University reports that adults currently using GLP-1 receptor agonist medications—including semaglutide brands Ozempic and Wegovy—showed a substantially weaker association between impulsivity and self-reported violent behavior than former users. The research, published June 17, 2026 in the journal Criminology, was based on a 2025 U.S. survey and does not establish cause and effect.

Stanford Medicine researchers say they have identified a naturally occurring 12–amino-acid peptide, BRP, that suppressed appetite and reduced body weight in animal studies. The team used a computational tool dubbed “Peptide Predictor” to identify the molecule, and reported that BRP produced anti-obesity effects in mice and minipigs without signs of nausea- or aversion-like responses seen with some GLP-1–based drugs.

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