Serena Williams, fit and transformed, poses athletically with tennis racket against Super Bowl ad for Zepbound weight loss drug.
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Serena Williams appears in Super Bowl ad for weight loss medication

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Serena Williams is set to feature in a Super Bowl commercial promoting the telehealth firm Ro and its GLP-1 weight loss medication Zepbound. The 44-year-old tennis legend discusses her body transformation, having lost up to 15.4kg since starting the treatment. The ad comes amid ongoing speculation about a potential return to professional tennis.

Ron Rosas, a 55-year-old amateur from Dallas, is planning a return to competitive tennis after losing all four limbs in a 2023 medical emergency. The former Notre Dame star aims to compete in the quad wheelchair division at this year's US Open. Despite recent setbacks, Rosas expresses unwavering passion for the sport.

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Serena Williams has been officially reinstated to compete in professional tennis as of February 22, 2026, after completing required testing protocols. Her former coach, Rick Macci, is certain she will return soon, potentially at the Indian Wells Open or Miami Open in March. The 23-time Grand Slam champion retired in 2022 but has been training actively.

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