Diego Santilli shakes hands with President Javier Milei during his appointment as Argentina's new interior minister in a celebratory government ceremony.
Diego Santilli shakes hands with President Javier Milei during his appointment as Argentina's new interior minister in a celebratory government ceremony.
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Diego Santilli appointed as new interior minister

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President Javier Milei appointed Diego Santilli as the new interior minister on November 2, 2025, replacing Lisandro Catalán. Santilli, a PRO leader and elected deputy from Buenos Aires who will not take his seat, will negotiate with governors and legislators to advance structural reforms. The announcement drew celebrations from the government and allies, praising his experience in dialogue and management.

Javier Milei announced Diego Santilli's appointment via X on Sunday afternoon: “WE HAVE AN INTERIOR MINISTER: Welcome Colo Santilli. Diego will lead conversations with governors and legislators to articulate with the National Congress each of the necessary consensuses for the reforms ahead for the future”. Santilli, former deputy head of the Buenos Aires government, met with Milei that evening at the Quinta de Olivos. Upon leaving, he told LN+: “The task is to add up. Add up to achieve important reform goals. The President has committed and is fulfilling. I have a huge job: budget, labor modernization, tax cuts, Penal Code”.

The appointment strengthens the alliance between La Libertad Avanza and PRO amid Cabinet changes following the legislative elections. Santilli, who headed the officialist list in Buenos Aires, will not assume his deputy seat, similar to Manuel Adorni, appointed chief of staff. This revives debate over testimonial candidacies.

Political figures celebrated the decision. Mauricio Macri posted on X: “It is a very positive incorporation for the Government. As a PRO leader with great experience, I trust that... he will be able to articulate with the governors the implementation of the reforms we need”. Patricia Bullrich added: “More and more of us are pushing this change with strength and conviction. Many successes in this new challenge, @diegosantilli. I know you will give it your all as always”. PRO issued a statement: “His incorporation is great news for the country and an opportunity to strengthen management and dialogue with the provinces”.

Other greetings came from Luis Caputo (“Congratulations and welcome @diegosantilli!!”), Martín Menem (“His management experience and role in the Chamber... will be key to strengthening federalism”) and Chubut Governor Ignacio Torres (“Congratulations @diegosantilli!!! I wish you success... we will support you”). Governors aligned with the government valued Santilli's dialogic profile to advance reforms with federal consensus. Adorni called a Cabinet meeting for Monday at 9:30 a.m. in the Casa Rosada, prioritizing reforms toward prosperity.

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President Javier Milei with Diego Santilli and Karina Milei at Quinta de Olivos for the cabinet appointment announcement.
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Javier Milei appoints Diego Santilli as new Chief of Cabinet replacing Manuel Adorni

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President Javier Milei announced on Sunday the appointment of Diego Santilli as new Chief of Cabinet following Manuel Adorni's resignation. The change was made official with a photo at Quinta de Olivos alongside Karina Milei.

Interior Minister Diego Santilli announced that the government will push a tax reform in Congress in coming months. The plan aims to deepen tax cuts and involve national, provincial, and municipal levels. He made the statements at the AmCham Summit 2026.

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Presidency's general secretary Karina Milei led a meeting on Tuesday at Casa Rosada with governors Rogelio Frigerio of Entre Ríos and Alfredo Cornejo of Mendoza. The gathering confirmed a decree allowing provinces to promote private investments for works on sections of national routes within their territories. Interior Minister Diego Santilli and Subsecretary Eduardo “Lule” Menem also attended.

President José Antonio Kast completed a cabinet adjustment on May 19, the fastest since the return to democracy. The departures included ministers Mara Sedini and Trinidad Steinert. Days later, additional modifications were recorded in the team at the Segundo Piso of La Moneda.

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In the ongoing investigations into Chief of Cabinet Manuel Adorni's foreign trips and properties—following his March resumption of press conferences—President Javier Milei chaired a cabinet meeting on April 6 at Casa Rosada, explicitly handing control to Adorni and renewing support amid judicial scrutiny. New details reveal Adorni received US$100,000 via mortgage from two women linked to his prior apartment purchase. Adorni later met Security Minister Alejandra Monteoliva.

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