The NBA's nine-game slate on Wednesday, November 19, 2025, tips off at 7 p.m. ET, featuring competitive matchups and blowout risks. Top DFS targets include Tyrese Maxey, Nikola Jokić and Karl-Anthony Towns, amid several injury concerns across teams. High totals like Chicago-Portland at 242.5 points promise scoring opportunities.
Wednesday's NBA action presents a mix of tight contests and potential blowouts, with spreads highlighting risks in games like Sacramento at Oklahoma City (-17.5 favoring OKC), Washington at Minnesota (-16 for MIN) and Denver at New Orleans (-13.5 for DEN). The Chicago Bulls-Portland Trail Blazers matchup boasts the highest projected total at 242.5, while New York Knicks-Dallas Mavericks sits lowest at 225.5.
In Philadelphia's game against Toronto, favored by 2.5 points, Tyrese Maxey stands out as a core play. He leads the league with 40.4 minutes per game and 23.6 field goal attempts, averaging 32.5 points, 3.8 made 3-pointers at 41.3% and 7.7 assists in November. However, the 76ers face injury woes: Joel Embiid is doubtful with knee soreness, Paul George is out (knee), Kelly Oubre Jr. out (knee) and Adem Bona out (ankle). Quentin Grimes could see increased minutes, averaging 16.8 points, 3.8 rebounds and 4.3 assists off the bench.
For Minnesota's heavy favoritism over Washington, Julius Randle has elevated his game, averaging 24.5 points, 6.1 assists and 1.3 steals—his highest scoring mark since joining the Timberwolves. Jaden McDaniels is questionable (wrist), while Washington's Alexandre Sarr is questionable (toe). Naz Reid offers value, averaging 17.7 points and 10 rebounds in 26.2 minutes over his last three games.
Denver's Nikola Jokić dominates November stats with 34.8 points, 12.8 rebounds, 11.3 assists and 1.8 steals, facing a Pelicans defense ranked 27th in efficiency. In New York vs. Dallas, Karl-Anthony Towns averages 30.5 points and 13 rebounds without Jalen Brunson, who is questionable (ankle). Mikal Bridges stepped up recently with 23 points, four blocks and two steals amid OG Anunoby's hamstring absence.
Other targets include Josh Giddey (23.5 points, 13.5 rebounds, 9.5 assists last two games) against Portland and Donovan Mitchell (32.8 points in November) in a high-scoring Cleveland-Houston matchup. Rookie Kon Knueppel averages 21.6 points over eight games for Charlotte.