In the January 29 episode of Grey's Anatomy season 22, Addison Montgomery returns to Grey Sloan Memorial, bringing urgent medical news and a personal bombshell about her marriage to Amelia Shepherd. The episode explores tensions in Addison's relationship with husband Jake while addressing patient crises and hospital staff developments.
The episode opens with Addison arriving at Grey Sloan Memorial to consult on a pregnant patient named Emma, who is suffering from unusual headaches. Scans reveal a brain tumor, prompting Addison to insist that Amelia, on sabbatical, assist in the surgery despite her reluctance. During preparations, Addison reveals the reason for her intensity: her husband Jake is leaving her. "Jake's leaving me. I don't want to talk about it. I don't want you to ask any questions about it. All I want is for Emma to get the best care possible, and that's you," she tells Amelia.
Amelia presses for more details, learning that Jake no longer supports Addison's work on the PRT program and wants her to return home. "Jake's done supporting my work on the PRT and wants me to come home. Happy?" Addison snaps. Tensions escalate during the operation, with Addison raising her voice and slamming her hands on a cart, leading Amelia to eject her: "Dr. Montgomery needs a minute."
After a FaceTime call with Richard, who advises her to accept accountability, Addison reconciles with Amelia. She shares that Jake once sent care packages and discussed cases with her, but now complains about her absence. "But I can't stomach sitting on the sidelines and watching people die, so I'm going to choose work," Addison confesses, even if it ends her marriage. Amelia notes that Jake's ultimatum indicates their relationship was already fractured.
Jake, played by Benjamin Bratt in the spin-off Private Practice, married Addison in that show's 2013 finale and has not appeared on Grey's Anatomy.
Elsewhere, Jo receives approval for discharge with her babies but stresses over an unfinished nursery and lack of a night nurse. Link suggests they take leave together, hiding his worsening hand injury from the hospital explosion, which flares up during surgery on a male stripper injured by baby oil.
Katie celebrates her tumor shrinking from a clinical trial but learns the funding has ended abruptly. Bailey delivers the news and vows to fight on, while Katie breaks down in tears.
In lighter moments, Kwan and Mohanty agree to exclusivity after he notices her food app activity. Simone and Wes resolve work tension with Wes performing a striptease to Ginuwine's "Pony."