The Los Angeles Rams (9-3) face the Arizona Cardinals (3-9) on Sunday in Week 14 at State Farm Stadium, with the Rams aiming to rebound from a loss to Carolina and extend their lead in the NFC West. Arizona, mired in a four-game skid, will be without key players including quarterback Kyler Murray for the season and several offensive starters due to injuries. Betting odds list the Rams as 9.5-point road favorites with an over/under of 49 points.
Game Preview
The Los Angeles Rams, tied atop the NFC West with Seattle, travel to Glendale, Arizona, to take on the last-place Cardinals in a crucial divisional matchup. Kickoff is scheduled for 4:25 p.m. ET on FOX, with streaming available on Fubo. The Rams enter with an 8-4 record against the spread and a 5-7 mark to the over, while Arizona stands at 6-6 ATS and 7-5 to the over despite their struggles.
Los Angeles is coming off a defeat to Carolina, dropping them to 9-3 overall, but they remain strong contenders. The Cardinals have lost four straight and sit at 3-9, positioning them for a potential high draft pick. Odds from sportsbooks have the Rams as -9.5 favorites, with a moneyline of -505 and the Cardinals at +384 underdogs. The total points line is set at 49.
Injury Impact on Cardinals
Arizona faces significant challenges due to injuries. Quarterback Kyler Murray, sidelined since Oct. 5 with a foot injury, will miss the rest of the 2025 season, as confirmed by coach Jonathan Gannon. Wide receivers Marvin Harrison Jr. (heel) and Greg Dortch (chest) are ruled out, along with running backs Trey Benson (knee) and Emari Demercado (ankle). Defensively, cornerback Max Melton (heel), defensive tackle Walter Nolen III (knee), safety Dadrion Taylor-Demerson (ankle), and defensive lineman L.J. Collier (knee, personal) will also sit. Questionable players include guard Evan Brown (personal), wide receiver Xavier Weaver (hamstring), and offensive lineman Kelvin Beachum (groin).
For the Rams, cornerback Darious Williams (tibia) is doubtful, while defensive tackle Poona Ford (calf) and wide receiver Tutu Atwell (hamstring) are questionable.
Betting and Prediction
A same-game parlay suggestion includes the Rams -9.5, under 49, and Cardinals tight end Trey McBride scoring a touchdown anytime at +135 odds, paying +721. The SportsLine model, simulating games 10,000 times, projects a Rams win in 70% of scenarios, covering in about half, with the under hitting 54% of the time. Predicted score: Rams 29, Cardinals 19.
This matchup highlights the disparity in the NFC West, with the Rams seeking to solidify their position while the Cardinals grapple with adversity.
