Injuries continue to mount as teams prepare for week 15 of the 2025 NFL season, impacting several high-profile players across the league. Quarterbacks Jayden Daniels and Geno Smith are ruled out, while running back Christian McCaffrey is questionable with a back issue. These absences could alter betting lines and game strategies in crucial late-season contests.
Week 15 of the 2025 NFL season brings a wave of injuries that bettors and fans must monitor closely. In the AFC North matchup between the Ravens and Bengals, Cincinnati wide receiver Tee Higgins is out with a concussion, his second in the last month. The Ravens, at 6-7, seek a win to stay in the division race.
The Raiders face the Eagles without quarterback Geno Smith, sidelined by right shoulder and back injuries; Kenny Pickett will start. Philadelphia's offensive tackle Lane Johnson is also out with a foot injury.
Arizona's Marvin Harrison Jr. (heel) is out against the Texans, where Houston's Nick Chubb (ribs) is questionable. The Chargers list Quentin Johnston (groin) as questionable versus the Chiefs, who will miss Hollywood Brown (personal), Trey Smith, and Jawaan Taylor.
The Jets have major quarterback issues with Tyrod Taylor (groin) and Justin Fields (knee) out, turning to rookie Brady Cook, and tight end Mason Taylor (neck) sidelined against the Jaguars.
Washington's Jayden Daniels is out with a left elbow injury after a brief return last week; Marcus Mariota starts, with Deebo Samuel (illness) and Chris Rodriguez (groin) questionable versus the Giants.
Cleveland misses tight end David Njoku (knee), running back Dylan Sampson (calf and hand), and cornerback Denzel Ward (calf) against the Bears, where Rome Odunze (foot) is questionable.
New Orleans running back Alvin Kamara (knee and ankle) is out versus the Panthers. Detroit's safeties Brian Branch and Kerby Joseph are out against the Rams, where Davante Adams (hamstring) is questionable.
Indianapolis deals with quarterback uncertainty after Daniel Jones' season-ending Achilles tear; Riley Leonard (knee) is active but Sauce Gardner (calf) is out versus the Seahawks.
Green Bay's Josh Jacobs (knee) is questionable against the Broncos. San Francisco's Christian McCaffrey was added to the injury report Saturday with a back issue, making him questionable versus the Titans despite a full Friday practice after an earlier illness. McCaffrey leads the 49ers with 849 rushing yards, 806 receiving yards, and 13 touchdowns; Brian Robinson could see more action, averaging 4.6 yards per carry. The 9-4 49ers host the 2-11 Titans.
Dallas tight end Jake Ferguson (calf) is questionable but CeeDee Lamb has cleared concussion protocol versus the Vikings. Pittsburgh's T.J. Watt is out with a collapsed lung requiring surgery against the Dolphins on Monday.
The Bills-Patriots game has no major injuries noted.
