New research in mice suggests that ovaries undergo significant changes after reproductive decline, potentially contributing to inflammation. Scientists found increased immune cell activity in aged ovaries.
Researchers at Northwestern University examined ovaries from mice at different ages. They compared young mice aged two months with reproductively old mice at 18 months and post-reproductive mice at 24 months.
The study revealed that older ovaries lost egg-producing follicles and showed more scarring. Genes tied to reproduction and hormone production declined, while those linked to inflammation and immune function increased.
Francesca Duncan, who led the work, said the findings were surprising. She noted that the ovaries appear to shift from a reproductive role toward an immune signature.
Similar changes may occur in humans, according to Diana Laird at the University of California, San Francisco. Further studies are needed to determine effects on overall health.
