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Bootstrap Bio and Manhattan Genomics, biotech firms launched last year to pursue human embryo editing for preventing serious diseases, have closed their doors. The companies cited financial difficulties and internal conflicts as reasons for the shutdowns. The developments highlight challenges in the controversial field of gene-edited babies.

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Paterna Biosciences, a startup based in Utah, says it has successfully produced functional human sperm from stem cells in a laboratory setting. The company used this lab-grown sperm to create visibly healthy-looking embryos. The achievement could one day assist men with specific infertility issues in having biological children.

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