Telomeres
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Scientists identify key role for RPA in telomere maintenance
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Researchers at the University of Wisconsin–Madison have shown that the protein replication protein A (RPA) is essential for telomerase activity that helps maintain long, healthy telomeres. The work, reported in the journal Science, sheds light on previously unexplained cases of short telomere disorders and may open new diagnostic avenues for patients with conditions such as aplastic anemia and certain leukemias.