Schizophrenia
Common acne drug may protect against schizophrenia
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A large Finnish registry study suggests that doxycycline, an antibiotic widely used for acne, may lower the risk of schizophrenia among adolescents receiving mental health care, with teens prescribed the drug showing roughly a 30–35% reduced risk compared with peers given other antibiotics.
MIT-led researchers report that a schizophrenia-associated mutation in the gene GRIN2A reduces activity in a mediodorsal thalamus–prefrontal cortex circuit that helps the brain update beliefs using new information. In experiments, mice carrying the mutation were slower to shift choices as reward conditions changed, and optogenetic activation of mediodorsal thalamus neurons made their behavior more similar to unaffected mice, the team reports in Nature Neuroscience.
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Researchers at UNSW Sydney report evidence that auditory verbal hallucinations in schizophrenia-spectrum disorders may involve a breakdown in the brain’s normal ability to dampen responses to self-generated inner speech, causing internally generated thoughts to be processed more like external sounds.