A mother’s mind appears restored: ultrasound may cure Alzheimer’s

A Chinese neurologist noticed unexpected improvements in his mother’s cognition during a high-intensity focused ultrasound (FUS) treatment for another condition, sparking hope for Alzheimer’s therapy. Dr. Sun Bomin claims this is the world’s first effective FUS treatment for the disease. His mother, in her nineties and suffering for about eight years, showed remarkable recovery in 2024.

Neurologist Sun Bomin, based in Shanghai, treated his mother with high-intensity focused ultrasound (FUS) in 2024 for a separate condition, only to witness a surprising revival in her Alzheimer’s-afflicted mind. The patient, in her nineties, had endured the progressive disorder for around eight years, which had wiped out memories, eliminated her sense of time, and rendered her passively silent—even unresponsive to a close family member’s death.

On January 21, Sun shared a short video on China’s Yitiao.tv platform and an accompanying article, proclaiming it the world’s first effective FUS treatment for Alzheimer’s. Post-procedure, his mother began recognizing family members, performing calculations, responding appropriately, and voicing emotional needs. Notably, she demonstrated the ability to count backwards from 100 by sevens, a key diagnostic test for dementia.

The event ties to Hangzhou in Zhejiang province, with Sun affiliated to Shanghai Ruijin Hospital and Fudan University. Keywords highlight figures like Wang Guifang and technologies such as MRI, alongside the World Society for Stereotactic and Functional Neurosurgery. While promising, this single case requires broader clinical validation to assess its potential as a cure.

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MIT researcher using focused ultrasound on volunteer's head to test consciousness theories, with holographic brain visualization.
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MIT paper lays out how focused ultrasound could test theories of consciousness

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Researchers affiliated with MIT argue that transcranial focused ultrasound—a noninvasive technique that can modulate activity in deep brain regions—could enable more direct, cause-and-effect tests of how conscious experiences arise. In a “roadmap” review in *Neuroscience & Biobehavioral Reviews*, they describe experimental approaches aimed at distinguishing between competing accounts of where and how awareness is generated in the brain.

Researchers have demonstrated that restoring levels of a key brain energy molecule can reverse advanced Alzheimer's disease in mouse models, repairing damage and restoring cognitive function. The study, published on December 22, challenges the long-held view that the condition is irreversible. Findings from human brain tissue support the approach's potential relevance to patients.

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Scientists at Northwestern University have identified a toxic subtype of amyloid beta oligomers that triggers early Alzheimer's changes in the brain. Their experimental drug, NU-9, reduced this damage and inflammation in pre-symptomatic mice, suggesting potential for preventing the disease before symptoms appear. The findings highlight a new strategy for early intervention.

An experimental gene therapy has demonstrated significant promise in slowing the progression of Huntington’s disease, a rare form of dementia, by about 75 percent in a late-stage trial. Researchers hailed the breakthrough as a major step forward, though challenges remain in delivery and regulatory approval. Efforts are underway to develop a more practical version of the treatment.

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A small randomized, double-blind trial suggests that MRI-based measures of brain structure may help predict which patients with major depressive disorder will show early symptom improvement after treatment with the traditional Chinese medicine Yueju Pill. In the four-day study, Yueju Pill and escitalopram were both associated with lower depression rating scores, but only Yueju Pill was linked to a rise in blood levels of brain-derived neurotrophic factor (BDNF).

Two Chinese patients with high-level paralysis have successfully used brain-machine interface (BMI) technology to control a power wheelchair, direct a robotic dog to retrieve deliveries, and operate a robotic arm to grasp a cup and drink water using only their thoughts. The achievements were announced on Wednesday at a media briefing by the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences in Shanghai. This marks a major advancement toward practical clinical applications of BMI.

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Consciousness expert Steven Laureys has joined Hangzhou Normal University, praising China's opportunities in science amid challenging times in the US. He highlights China's efficient resource unification and collaborative push.

 

 

 

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