This week saw U.S.-based startups raise significant venture capital, led by $500 million rounds for cryptocurrency firm Ripple and AI parking platform Metropolis. The funding spanned sectors including biotech, cybersecurity, and neurotech. The total for the top 10 rounds exceeded $2 billion, highlighting continued investor interest in innovative technologies.
From November 1 to 7, 2025, U.S. startups announced some of the largest funding rounds of the year, according to Crunchbase data. The week was marked by two tied-for-first-place deals at $500 million each.
San Francisco-based Ripple, a cryptocurrency payments company, raised $500 million at a $40 billion valuation. The round was led by funds managed by affiliates of Fortress Investment Group and Citadel Securities, with participation from Pantera Capital, Galaxy Digital, Brevan Howard, and Marshall Wace.
Tied with Ripple, Los Angeles-based Metropolis, an AI-powered checkout-free parking platform, secured $500 million in Series D equity financing at a $5 billion valuation, part of a total $1.6 billion in debt and equity. LionTree led the equity portion, while JP Morgan Chase Bank provided a $1.1 billion term loan.
Other notable rounds included Armis, a San Francisco cybersecurity firm, closing $435 million in pre-IPO funding led by Goldman Sachs Growth Equity, valuing the 10-year-old company at $6.1 billion. New York-based Synchron, developing nonsurgical brain-computer interfaces for paralysis patients, raised $200 million in Series D funding led by Double Point Ventures.
Palo Alto's Hippocratic AI, focused on generative AI healthcare agents, landed $126 million in Series C led by Avenir, reaching a $3.4 billion valuation. MoEngage, an AI customer engagement platform, raised $100 million, with Goldman Sachs Alternatives and A91 Partners leading; 60% went to the company and 40% to secondary share sales.
Additional deals featured Austin's Infravision ($91 million Series B for aerial robotics, led by GIC), Santa Clara's Reevo ($80 million for AI go-to-market tools, co-led by Khosla Ventures and Kleiner Perkins), Palo Alto's Neok Bio ($75 million from stealth for biotech, backed by ABL Bio), and Berkeley's Azalea Therapeutics ($65 million Series A for genomic medicines, led by Third Rock Ventures).
These rounds reflect a diverse investor appetite across crypto, AI, biotech, and more, tracked from Crunchbase's database of U.S.-based companies.