DNA Damage
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Researchers identify sticky mitochondrial DNA damage tied to cellular stress and disease risk
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Scientists at the University of California, Riverside have identified a previously unknown form of mitochondrial DNA damage known as glutathionylated DNA adducts, which build up at dramatically higher levels in mitochondrial DNA than in nuclear DNA. The lesions disrupt energy production and activate stress-response pathways, and researchers say the work could help explain how damaged mitochondrial DNA contributes to inflammation and diseases including diabetes, cancer and neurodegeneration.