Chemotherapy
Natural compound may enhance chemotherapy for aggressive leukemia
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Researchers linked to the University of Surrey report that forskolin, a plant-derived compound, can slow the growth of KMT2A‑rearranged acute myeloid leukaemia cells in the lab and increase their sensitivity to the chemotherapy drug daunorubicin. The findings, from a study published in the British Journal of Pharmacology, suggest a possible way to make existing treatments more effective, though further research is required before any change to clinical practice.
A new study reveals that the MYC protein does more than drive tumor growth. It also repairs DNA damage in cancer cells, allowing some tumors to survive chemotherapy and radiation.
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Scientists have identified a molecule produced by bacteria inside tumors that enhances the effectiveness of chemotherapy against colorectal cancer. The compound, 2-methylisocitrate, damages cancer cell DNA and disrupts their metabolism. This discovery could lead to new treatments that make existing drugs more potent.