Medical Breakthrough
Blocking FSP1 triggers ferroptosis, curbing lung tumors in mice
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Researchers at NYU Langone Health report that inhibiting the protein FSP1 induces ferroptosis and markedly slows lung adenocarcinoma in mouse models. The study, published online in Nature on November 5, 2025, found tumor growth reductions of up to 80% in preclinical tests, according to the institution.
Researchers have discovered that cancer cells respond to physical squeezing by rapidly deploying mitochondria to the nucleus, delivering a burst of ATP to repair DNA damage and ensure survival. This mechanism, observed in lab experiments and patient biopsies, could inspire new strategies to halt cancer spread. The finding redefines mitochondria's role as dynamic responders rather than static energy sources.
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Researchers have identified a novel protein biomarker that detects lung cancer at an early stage with high accuracy. The discovery, detailed in a recent study, could enhance screening methods and improve patient outcomes. Clinical trials showed promising results in identifying the disease before symptoms appear.