Osteoporosis
Study in rats finds long-term omeprazole use disrupts mineral levels linked to anemia and bone health risks
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Researchers in Brazil report that prolonged use of the proton pump inhibitor (PPI) omeprazole altered iron and calcium measures in adult rats and shifted how several minerals were distributed across organs—changes they say are consistent with higher risks of anemia and possible bone health harms. The authors and Brazil’s health regulator stress that PPIs remain effective for acid-related disorders, but warn against extended, unsupervised use.
A major new analysis of nearly 154,000 adults shows that calcium and vitamin D supplements provide little to no protection against fractures or falls for most older people. The findings, published in The BMJ, challenge long-standing recommendations for routine use of these supplements.
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Scientists at the University of Hong Kong have uncovered a protein that acts as an exercise sensor in bones, explaining how movement prevents age-related bone loss. This discovery could lead to drugs mimicking exercise benefits for those unable to stay active. The findings highlight potential new treatments for osteoporosis affecting millions worldwide.