In the pivotal Week 16 of the 2025 NFL season—with clinching opportunities for multiple teams detailed in our prior coverage—CBS Sports and SportsLine experts deliver predictions and best bets. Odds via DraftKings Sportsbook feature spreads like Bills (-10) vs. Browns and Ravens (-3) vs. Patriots on Sunday Night Football.
The Week 16 slate opens Saturday with Eagles (10-5) at Commanders and Packers at Bears (10-4), a key NFC North battle where Chicago can clinch with a win and Lions loss/tie.
Pete Prisco predicts Bills (10-4) 27-14 over Browns (3-11), covering -10, thanks to Josh Allen. Bengals at Dolphins (both eliminated): Prisco likes Miami +4.5 (30-26). Chiefs (-3.5, no Mahomes) beat Titans despite elimination.
Afternoon: Jared Dubin picks Chargers (10-4) +2.5 at Cowboys (6-7-1) amid Dallas' defensive woes. Tyler Sullivan backs Panthers +3 vs. Buccaneers (7-7), citing Tampa's poor run defense (29.3 PPG allowed recently). John Breech likes Broncos (12-2) -3 vs. Jaguars (10-4) to clinch AFC's No. 1 seed.
Late: Dubin favors Lions (8-6) -7 over Steelers (8-6), expecting Jahmyr Gibbs' bounce-back. Prisco sees Texans (-14.5) 31-9 over Raiders. SportsLine model (up $7,000) projects Buccaneers 28-22 vs. Panthers and leans Under 48.5, Ravens -3 vs. Patriots (11-3). Monday: Jordan Dajani picks 49ers (10-4) -6.5 at Colts (8-6) on offensive momentum.
Simulations run 10,000 times highlight high stakes for contenders like Denver, which clinches top seed with win + losses by Chargers, Patriots, Bills.