The Los Angeles Rams visit the San Francisco 49ers in a pivotal NFC West clash on Sunday, November 9, at Levi's Stadium. The 6-2 Rams seek revenge after a 26-23 overtime loss to the 6-3 49ers in Week 5. Kickoff is set for 4:25 p.m. ET on FOX.
The NFC West remains competitive as the Los Angeles Rams (6-2) travel to face the San Francisco 49ers (6-3) in their second meeting of the season. The 49ers claimed a 26-23 overtime victory in Week 5 on Thursday Night Football, totaling 49 points in that contest. This rematch carries implications for division standings, with both teams vying for positioning atop the loaded conference.
The game airs on FOX with streaming available on Fubo, starting at 4:25 p.m. ET from Levi's Stadium in Santa Clara, California. Betting odds show the Rams as road favorites, though reports vary: one consensus lists them at -6 with an over/under of 49.5, while another has them at -4.5. The Rams are -250 on the money line, with the 49ers at +200.
Los Angeles has excelled straight up and against the spread, going 6-2 in both. Since the Week 5 loss, the Rams have won three straight, outscoring opponents 86-20. Quarterback Matthew Stafford leads the NFL with 21 passing touchdowns and 2,147 yards, including a 375-yard, three-touchdown performance against San Francisco earlier. He has thrown 16 touchdowns with zero interceptions over his last five games. Receivers Puka Nacua and Davante Adams form a potent duo, with Adams leading the league with eight receiving touchdowns. Nacua is expected to play despite a recent rib injury. Running back Kyren Williams is highlighted in same-game parlays for an anytime touchdown.
The 49ers, quarterbacked by Mac Jones due to Brock Purdy's turf toe injury limiting him to two games, rely heavily on Christian McCaffrey. He leads the NFL with 1,222 yards from scrimmage and is on pace for another 1,000-1,000 rushing-receiving season. However, San Francisco has battled injuries, with Fred Warner, Nick Bosa, and rookie Mykel Williams out for the season, plus absences for George Kittle, Ricky Pearsall, Jauan Jennings, and Brandon Aiyuk yet to debut.
The Rams' defense ranks top-10 in key metrics like yards per play allowed, sacks (Byron Young with nine), and red-zone efficiency. A SportsLine model simulation predicts a low-scoring affair at Rams 24-21, favoring the under on 49.5 total points in 63% of 10,000 runs. Another expert pick leans Rams -4.5 and over 49.5, noting the last five meetings decided by seven points or fewer.