The medical dramedy Best Medicine, starring Josh Charles as a surgeon transitioning from Boston to the small Maine town of Port Wenn, premiered January 4, 2026. Follow-up episodes continue Tuesdays at 8/7c starting January 13.
TVLine highlighted the Best Medicine debut in its What to Watch column for January 4, amid a slate of new and returning shows including the Critics Choice Awards hosted by Chelsea Handler at the Barker Hangar in Santa Monica and the Season 13 return of When Calls the Heart. The premiere day also featured celebrity cooking competitions and sports finales.
The AV Club included Best Medicine in its January 4-10 watch guide, alongside newcomers like The Pitt and a miniseries starring Tessa Thompson and Jon Bernthal. This launch introduces a character-driven story of professional reinvention and rural community life to viewers, fitting into a bustling programming weekend.