Betting markets show the Buffalo Bills as strong favorites to surpass 10.5 victories in the upcoming 2026 NFL campaign. The New England Patriots face a tougher schedule after their 2025 success. Other AFC East teams project lower totals.
DraftKings Sportsbook lists the Buffalo Bills at an over/under of 10.5 wins for 2026, with the over priced at minus 125. The team enters the year with new head coach Joe Brady following the firing of Sean McDermott after a divisional round playoff loss in overtime to the Denver Broncos during the 2025 season. Buffalo opens against the Houston Texans, Detroit Lions, Los Angeles Chargers, New England Patriots and Los Angeles Rams.
