Several key quarterbacks are sidelined for Week 10 due to injuries, including Houston Texans' C.J. Stroud with a concussion and Washington Commanders' Jayden Daniels with an elbow issue. San Francisco 49ers will start Mac Jones again as Brock Purdy remains questionable with a toe injury, while Arizona Cardinals' Kyler Murray is on injured reserve.
As the NFL enters Week 10 of the 2025 season, injuries continue to shape matchups across the league. Houston Texans quarterback C.J. Stroud is ruled out with a concussion sustained last week against the Denver Broncos, paving the way for Davis Mills to start against the Jacksonville Jaguars. Stroud did not practice all week.
Washington Commanders quarterback Jayden Daniels is out with a left elbow injury from the previous week's loss to the Seattle Seahawks. An MRI showed no ligament damage or need for surgery, and Daniels is expected to be re-evaluated after the team's Week 12 bye. He is not being placed on injured reserve.
In San Francisco, head coach Kyle Shanahan confirmed Mac Jones will start his eighth game of the season against the Los Angeles Rams, despite Brock Purdy being listed as questionable with a toe injury. Purdy, who last played in Week 4, has been progressing but will not start. Shanahan noted Purdy is 'getting closer' to a return and could be active.
Arizona Cardinals placed Kyler Murray on injured reserve with a foot injury, meaning he will miss at least four games. Jacoby Brissett is set to start.
Other notable updates include Carolina Panthers running back Rico Dowdle cleared to play against the New Orleans Saints after upgrading from no practice Wednesday to full participation Friday with a quadriceps issue. Indianapolis Colts defensive tackle DeForest Buckner was placed on injured reserve with a neck injury, sidelining him for at least four games.
Philadelphia Eagles running back Saquon Barkley and wide receiver A.J. Brown have no injury designation after their bye, clearing them for Monday's game against the Green Bay Packers. Tampa Bay Buccaneers will be without running back Bucky Irving and wide receiver Chris Godwin Jr., both ruled out.
Teams like the Baltimore Ravens report no injury designations, entering their game against the Minnesota Vikings fully healthy.