Ageing
A Cold Spring Harbor Laboratory study demonstrated CAR T-cell therapy can reverse age-related intestinal decline in mice by targeting senescent cells. While promising, experts caution on safety risks, off-target effects, dosing, and costs for human use.
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A new study reveals that the trade-off between reproduction and longevity becomes evident only during harsh environmental conditions, such as famines. Researchers analyzed records of over 4,500 Finnish women across 250 years, finding that those who gave birth during the Great Finnish Famine of 1866-1868 had their life expectancy reduced by six months per child. This supports the disposable soma hypothesis but highlights its context-dependency.