Brain Development
Developing neurons sustain and rapidly repair DNA double-strand breaks during migration, study finds
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A study in Nature reports that newborn neurons can incur double-strand DNA breaks while squeezing through tight spaces in the developing brain, and that healthy cells typically repair most of this damage within about a day.
Researchers at the Institute of Science and Technology Austria have found that the brain's memory center, the hippocampus, begins life with a dense, seemingly random network of connections rather than a blank slate. This network refines itself through pruning, becoming more organized and efficient over time. The discovery challenges the traditional tabula rasa concept.
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A common belief that the frontal lobe fully develops by age 25 has been challenged by recent neuroscience findings. New brain-imaging studies reveal that key neural wiring and network efficiency evolve well into the early 30s. This extended timeline highlights ongoing maturation processes in the brain.