Human Biology
Study identifies DHX29 as a key factor linking codon choice to selective silencing of inefficient genetic messages in human cells
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Researchers at Kyoto University and RIKEN report that human cells can detect “non-optimal” synonymous codons—alternative three-letter genetic instructions that encode the same amino acid but are translated less efficiently—and selectively suppress the corresponding mRNAs. In experiments described in Science, the team identifies the RNA-binding protein DHX29 as a central component of this codon-dependent control of gene expression.
New findings challenge the traditional view of five senses, proposing that humans could have between 22 and 33 distinct ones. These senses blend to create our perception of the world, influencing everything from taste to balance. Experts at the University of London highlight how everyday experiences reveal this complexity.
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Researchers have identified indole metabolites from the human blood bacterium Paracoccus sanguinis that showed anti-aging activity in laboratory-grown human skin cells. The compounds reduced oxidative stress, inflammation and collagen-degrading activity in cell experiments, according to findings published in the Journal of Natural Products.