Biophysics

Researchers redefine how key motor protein helps chromosomes align

10. desember 2025 Rapportert av AI Bilde generert av AI Faktasjekket

Researchers at the Ruđer Bošković Institute in Zagreb report that the protein CENP-E plays a crucial role in stabilizing the earliest attachments between chromosomes and microtubules during cell division, rather than mainly acting as a motor that pulls chromosomes into place. The work, described in two studies in Nature Communications, revises long-standing models of chromosome congression by linking CENP-E’s function to Aurora kinases and suggesting implications for understanding diseases marked by chromosome segregation errors.