Organic Chemistry
Researchers at the University of California, Los Angeles, have synthesized cage-shaped molecules featuring unusually warped double bonds, defying long-held principles of organic chemistry. This breakthrough builds on their 2024 overturning of Bredt's rule and could influence future drug design. The findings appear in Nature Chemistry.
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Researchers at Hokkaido University have developed a new catalytic method to generate ketyl radicals from alkyl ketones, solving a long-standing challenge in organic chemistry. Using a computational screening tool, the team identified an effective ligand that prevents unwanted electron transfer, enabling cleaner and more reliable reactions. This breakthrough aids natural product synthesis and pharmaceutical development.