Wounds and Healing
Low serine levels push hair follicle stem cells to repair skin, study finds
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Rockefeller University scientists report that, in mice, hair follicle stem cells switch from fueling hair growth to repairing wounds when the amino acid serine is scarce — a shift governed by the integrated stress response. The peer‑reviewed findings in Cell Metabolism suggest dietary or drug strategies could eventually help speed wound healing.
Researchers at NYU Langone Health have discovered a small molecule called RAGE406R that interrupts a harmful interaction between proteins RAGE and DIAPH1, reducing inflammation and tissue damage in diabetes. In mouse models of both Type 1 and Type 2 diabetes, the compound accelerated wound healing and lessened organ stress without lowering blood sugar levels. The findings, published in Cell Chemical Biology, suggest a novel approach to treating diabetes complications.