The Boston Celtics will face the Indiana Pacers at TD Garden on Wednesday night, looking to secure the season series in an Eastern Conference matchup. Both teams enter coming off losses, with significant injuries impacting their rosters. Boston is favored by 10.5 points according to betting odds.
The Boston Celtics (26-16), who lead the Atlantic Division, host the Indiana Pacers (10-34), fifth in the Central Division, on January 21, 2026, at 7:30 p.m. ET. The Celtics are 12-7 at home this season, while the Pacers hold a poor 2-18 road record. Indiana recently lost 113-104 to Philadelphia on Monday, and Boston fell 104-103 at Detroit the same day.
Injuries are a major factor: the Pacers will be without guard Benedict Mathurin due to a thumb issue and have struggled without Tyrese Haliburton, sidelined by an Achilles injury. The Celtics, meanwhile, are performing well despite missing Jayson Tatum to an Achilles problem, going 11-5 over their last 16 games.
Betting lines from DraftKings Sportsbook list Boston as a 10.5-point favorite, with an over/under of 226.5 points and a money line of Boston -495, Indiana +375. The SportsLine Projection Model, which simulates games 10,000 times, predicts the total will go over, noting it has happened in four of the last six head-to-head meetings. The model also projects the Celtics to cover the spread in 60-63% of simulations, highlighting Boston's 6-1 record against Indiana at home over the last three years, including playoffs.
Projections include Indiana's Pascal Siakam scoring 22.1 points, with four Pacers players reaching 10.3 or more, and Boston's Jaylen Brown at 29.8 points, with six Celtics scorers over 10 points. The Celtics are 24-18 against the spread this season, third-best in the league, while the Pacers are 5-5 ATS in their last 10 games and the Celtics 6-4.
