Developmental Biology
Scientists have discovered a novel way large embryonic cells divide without a complete contractile ring, challenging traditional models. Using zebrafish embryos, researchers identified a mechanical ratchet system involving microtubules and changing cytoplasmic stiffness. The findings, published in Nature, explain division in yolk-rich cells of various species.
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Researchers have discovered that DNA in newly fertilized eggs forms a structured 3D scaffold before the genome activates, challenging long-held assumptions. Using a new technique called Pico-C, scientists mapped this organization in fruit fly embryos. A related study shows that disrupting this structure in human cells triggers an immune response as if under viral attack.