NFL Week 16
49ers visit Colts in pivotal Monday Night Football clash
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The San Francisco 49ers, riding a four-game winning streak, face the struggling Indianapolis Colts on Monday Night Football with playoff implications on the line. San Francisco has clinched a postseason berth and eyes the NFC's top seed, while the Colts fight to stay alive in the wild-card race. Veteran quarterback Philip Rivers starts his second game for Indianapolis against Brock Purdy and the 49ers.
The Jacksonville Jaguars defeated the Denver Broncos 34-20 on Sunday, extending their winning streak to six games and bolstering their AFC playoff position. Trevor Lawrence threw for 279 yards and three touchdowns while adding a rushing score, showcasing the team's resurgence under coach Liam Coen. The victory snapped Denver's 11-game winning streak and highlighted Jacksonville's momentum as a small-market contender.
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In the pivotal Week 16 of the 2025 NFL season—with clinching opportunities for multiple teams detailed in our prior coverage—CBS Sports and SportsLine experts deliver predictions and best bets. Odds via DraftKings Sportsbook feature spreads like Bills (-10) vs. Browns and Ravens (-3) vs. Patriots on Sunday Night Football.
In a follow-up to Tuesday's announcement benching Tua Tagovailoa, the Dolphins will start rookie Quinn Ewers for the remainder of the 2025 season, beginning with Week 16 against the Cincinnati Bengals, who are coming off a 24-0 shutout loss to the Baltimore Ravens.
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The Miami Dolphins have benched quarterback Tua Tagovailoa in favor of seventh-round rookie Quinn Ewers for their Week 16 matchup against the Cincinnati Bengals. Coach Mike McDaniel stated that Ewers gives the team the best chance to win, following Tagovailoa's struggles this season. Tagovailoa, who leads the NFL with 15 interceptions, expressed disappointment but pledged to support the team.