Diet and Weight Loss

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Illustration depicting tirzepatide's temporary silencing of brain 'food noise' signals in a reward region before cravings return, based on deep-brain study.
Image generated by AI

Brain recordings hint tirzepatide may briefly quiet ‘food noise’ before cravings return

Reported by AI Image generated by AI Fact checked

In a rare deep-brain recording study of a woman with severe obesity and loss-of-control eating, tirzepatide — sold as Mounjaro and Zepbound — temporarily silenced activity in a key reward region linked to “food noise,” or intrusive thoughts about food. About five months later, those brain signals and intense food preoccupation reappeared, suggesting the drug’s effects on this patient’s cravings were short‑lived.

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