Gut Microbiome
Global study highlights ‘hidden’ gut bacteria CAG-170 as a potential marker of health
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Researchers led by the University of Cambridge report that an uncultured group of gut bacteria known as CAG-170 appears more abundant in healthy people and is less common in several chronic diseases, based on analysis of more than 11,000 gut metagenomes from 39 countries.
A retired US Marine officer in Massachusetts, plagued by a gut that brewed its own alcohol, has seen his symptoms resolve after receiving faecal transplants from a healthy donor. The treatment targeted the rare auto-brewery syndrome, where gut microbes ferment sugars into intoxicating levels of alcohol. This case highlights potential new avenues for managing the condition triggered by antibiotic use.
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An international team of researchers has identified trimethylamine (TMA), a gut microbe metabolite produced from dietary nutrients such as choline, as a compound that inhibits the immune-signalling protein IRAK4, dampening inflammation and improving insulin action in experimental models. The discovery, reported in Nature Metabolism, suggests a potential new way to counter some of the harmful metabolic effects of high-fat diets and opens avenues for future type 2 diabetes therapies, a disease affecting more than 500 million people worldwide.