Organic Chemistry
Researchers at the University of California, Los Angeles, have synthesized cage-shaped molecules featuring unusually warped double bonds, defying long-held principles of organic chemistry. This breakthrough builds on their 2024 overturning of Bredt's rule and could influence future drug design. The findings appear in Nature Chemistry.
Reported by AI
Researchers at Hokkaido University have developed a new catalytic method to generate ketyl radicals from alkyl ketones, solving a long-standing challenge in organic chemistry. Using a computational screening tool, the team identified an effective ligand that prevents unwanted electron transfer, enabling cleaner and more reliable reactions. This breakthrough aids natural product synthesis and pharmaceutical development.