Neurodegeneration
Toxic alliance of proteins may trigger Alzheimer's disease
Researchers at Rockefeller University have identified a harmful interaction between amyloid beta and fibrinogen that forms stubborn clots, damaging brain blood vessels and sparking inflammation even at low concentrations. This complex disrupts the blood-brain barrier and leads to early signs of neurodegeneration. The findings suggest a new target for early intervention in Alzheimer's disease.