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University of Sydney researchers examine a detailed fMRI brain scan highlighting pain-control areas in the brainstem, symbolizing advances in non-opioid pain treatments.
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Scientists map brainstem’s pain‑control network, pointing to targeted non‑opioid relief

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Using 7‑Tesla fMRI and a placebo paradigm, University of Sydney researchers mapped how the human brainstem modulates pain by body region. The study, published in Science on August 28, 2025, outlines a somatotopic system centered on the periaqueductal gray and rostral ventromedial medulla and suggests avenues for localized, non‑opioid treatments.

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