Diabetes
Global genomic study finds highly diverse E. coli strains in diabetic foot infections, including drug-resistant lineages
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A genomic analysis of Escherichia coli isolated from infected diabetic foot ulcers across 10 countries found no single dominant strain, instead revealing wide genetic diversity and a subset of isolates with markers of multidrug or extensive drug resistance, researchers from King’s College London and the University of Westminster report.
Brazil's Anvisa approved on Monday, February 2, 2026, the expansion of therapeutic indications for semaglutide, the active ingredient in Wegovy and Ozempic. Wegovy can now be used to reduce the risk of heart attacks and strokes in adults with cardiovascular disease and overweight, while Ozempic is indicated for type 2 diabetes associated with chronic kidney disease. The agency is also reviewing a request for an oral version of Wegovy.
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Researchers at the University of Osaka have found that sustained high blood sugar levels raise the risk of tooth decay as sugars transfer from blood to saliva. In a survey of around 60 diabetic and nondiabetic individuals, higher blood sugar was linked to increased glucose and fructose in saliva, along with greater tooth decay and plaque.
Health care company Abbott has introduced Libre Assist, a new AI-powered tool within its Libre app, designed to help people with diabetes assess the potential impact of their meals on glucose levels before eating. Users can simply photograph or describe their food to receive predictions and tips. The feature, unveiled at CES 2026, integrates with Abbott's FreeStyle Libre continuous glucose monitors for post-meal insights.
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Researchers at the University of Sydney have discovered that type 2 diabetes directly alters the heart's structure and energy production, increasing the risk of heart failure. By examining donated human heart tissue, the team identified molecular changes that stiffen the muscle and disrupt cellular function. These findings, published in EMBO Molecular Medicine, highlight a unique profile in patients with both diabetes and ischemic heart disease.
Researchers at Karolinska Institutet and Stockholm University have developed an experimental oral drug that boosts metabolism in skeletal muscle, improving blood sugar control and fat burning in early studies without reducing appetite or muscle mass. Unlike GLP-1-based drugs such as Ozempic, the candidate acts directly on muscle tissue and has shown good tolerability in an initial clinical trial, according to the study authors.
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A study in obese mice has found that the gut-derived hormone FGF19 can signal the brain to increase energy expenditure and activate fat-burning cells. Acting through the hypothalamus and the sympathetic nervous system, this mechanism enhances thermogenesis and cold tolerance and may help guide new treatments for obesity and diabetes.
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