Researchers at McMaster University and the Population Health Research Institute report that simple retinal scans, combined with genetic and blood data, may offer a non-invasive window into cardiovascular health and biological aging. An analysis of more than 74,000 people linked simpler eye-vessel patterns to higher heart-disease risk and faster aging. The study, published October 24, 2025, in Science Advances, points to potential early-detection tools that remain under investigation.
The tiny vessels in the eye may provide clues to heart-disease risk and the pace of biological aging, according to new research from McMaster University and the Population Health Research Institute (PHRI), a joint institute of Hamilton Health Sciences and McMaster. The team found that retinal vessel patterns reflecting lower branching complexity were associated with markers of cardiovascular risk and aging. (sciencedaily.com)
The peer-reviewed study was published in Science Advances on October 24, 2025. Investigators integrated retinal images, genetic data and blood biomarkers to probe shared pathways behind vascular aging and disease. (research.ed.ac.uk)
“By connecting retinal scans, genetics, and blood biomarkers, we have uncovered molecular pathways that help explain how aging affects the vascular system,” said senior author Marie Pigeyre, an associate professor in McMaster’s Department of Medicine and a scientist at PHRI. Pigeyre added that changes in retinal vessels often mirror those occurring in the body’s small vessels. (sciencedaily.com)
The analysis drew on data from 74,434 participants across four cohorts: the Canadian Longitudinal Study on Aging (CLSA), the Genetics of Diabetes Audit and Research Tayside (GoDARTS), the UK Biobank, and PHRI’s Prospective Urban and Rural Epidemiological (PURE) study, which supplied blood-protein biomarker data. (research.ed.ac.uk)
Individuals with simpler, less-branched retinal vessels were more likely to have cardiovascular disease, and genetic analyses linked this vessel pattern to increased inflammation and shorter lifespan, suggesting a faster aging process. The authors emphasize these findings identify associations and potential causal pathways rather than a stand‑alone diagnostic, and that retinal imaging would complement—not replace—broader clinical evaluation. (sciencedaily.com)
In follow-up analyses, the team highlighted proteins implicated in inflammation and vascular aging, including MMP12 and IgG‑Fc receptor IIb, as potential therapeutic targets identified through Mendelian randomization. (research.ed.ac.uk)
Funding was provided by the Canadian Institutes of Health Research, McMaster University’s E.J. Moran Campbell Internal Career Research Award, and Hamilton Health Sciences’ Early Career Research Award; CLSA retinal-image analyses received additional support from an HHS New Investigator Fund. (sciencedaily.com)
