Illustration showing long COVID patients revitalized by fluvoxamine treatment in a clinical trial, with scientists and physician highlighting study results.
Illustration showing long COVID patients revitalized by fluvoxamine treatment in a clinical trial, with scientists and physician highlighting study results.
Billede genereret af AI

Fluvoxamin lindrer svær træthed hos long-covid-patienter

Billede genereret af AI

Et studie viser, at antidepressivet fluvoxamin reducerer svær træthed hos long-covid-patienter. I et randomiseret forsøg med 399 voksne blev det sammenlignet med metformin og placebo. Overlæge Judith Bruchfeld betegner resultaterne som interessante.

Et nyt studie, som Dagens Medicin beretter om, har undersøgt behandlinger mod svær træthed hos voksne med long-covid – en træthed, der ikke forbedres ved hvile. 399 patienter blev randomiseret til at modtage fluvoxamin, type 2-diabetesmedicinen metformin eller placebo.

Fluvoxamin, der bruges mod depression, reducerede træthed effektivt. Metformin og placebo viste ingen tilsvarende effekt i studiet.

"Det er interessante data fra et veludført studie. Fluvoxamin er et velkendt lægemiddel med relativt få bivirkninger, som kan testes klinisk på udvalgte patienter," siger Judith Bruchfeld, overlæge i infektionsmedicin på Karolinska Universitetshospital, der forsker i long-covid, til avisen.

Lægemidlet sælges i Sverige under navnet Fevarin, men er ikke tilskudsberettiget.

Hvad folk siger

Reaktionerne på X til studiet om fluvoxamin og træthed ved long-covid er forsigtigt optimistiske, hvor både sundhedsfaglige og patienter bemærker dets lodtrækningsdesign og den signifikante reduktion af træthed sammenlignet med placebo. Skeptikere fremhæver den beskedne kliniske effektstørrelse og manglen på mekanistiske data. Metformin viste ingen fordel, og visse rejste bekymringer omkring bivirkninger ved SSRI-præparater.

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