Children's Health
Scientists raise MeCP2 levels by shifting MECP2 splicing in early Rett syndrome studies
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Researchers at Texas Children’s Hospital’s Duncan Neurological Research Institute and Baylor College of Medicine report an experimental gene-targeting approach designed to increase levels of the MeCP2 protein disrupted in Rett syndrome. In mouse experiments and neurons derived from patient cells, the strategy boosted MeCP2 and partially restored cellular structure, electrical activity and gene-expression patterns, according to findings published in Science Translational Medicine.
Exposure to certain per- and polyfluoroalkyl substances (PFAS), often called “forever chemicals,” during early childhood was associated with lower bone mineral density at age 12 in a U.S. birth cohort study published in the Journal of the Endocrine Society. The associations were strongest for perfluorooctanoic acid (PFOA) and appeared more pronounced in girls, while links for other PFAS varied by the timing of exposure.
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A new study in Gastroenterology connects early life stress to long-term gut issues through disruptions in gut-brain communication. Mouse experiments and large human cohorts show links to pain, constipation, and irritable bowel syndrome. Researchers suggest targeted treatments based on specific biological pathways.
Nearly one in five packaged foods and beverages sold by the top 25 U.S. manufacturers contain synthetic dyes, and products in categories heavily marketed to children are far more likely to include them and have higher sugar, according to new peer‑reviewed research.