Brain Cells
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Scientists identify a neuroprotective microglia subtype in Alzheimer’s
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A study published November 5 in Nature reports that a small subset of microglia marked by low PU.1 and expression of the receptor CD28 can dampen neuroinflammation and curb amyloid pathology in Alzheimer’s models, pointing to microglia-focused immunotherapy. The work draws on mouse experiments, human cells, and analyses of human brain tissue.