Brain Cells

Scientists identify a neuroprotective microglia subtype in Alzheimer’s

November 08, 2025 由 AI 报道 AI 生成的图像 事实核查

A study published November 5 in Nature reports that a small subset of microglia marked by low PU.1 and expression of the receptor CD28 can dampen neuroinflammation and curb amyloid pathology in Alzheimer’s models, pointing to microglia-focused immunotherapy. The work draws on mouse experiments, human cells, and analyses of human brain tissue.