Osteoarthritis
Stem cell ‘pain sponge’ therapy shows promise for osteoarthritis relief and joint protection
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SereNeuro Therapeutics has reported promising preclinical data for SN101, an induced pluripotent stem cell-based therapy for chronic osteoarthritis pain. The treatment uses engineered peripheral pain-sensing neurons that sequester inflammatory pain factors without transmitting pain signals, while releasing regenerative molecules that may help preserve cartilage, according to data presented at an International Society for Stem Cell Research symposium.
A minimally invasive procedure known as genicular artery embolization (GAE) was linked to sustained pain reduction and improved function for most people with osteoarthritis-related knee pain in a prospective, single-center study using rapidly resorbable gelatin-based microspheres, with follow-up reported out to 12 months.
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Researchers at the University of Colorado Boulder have demonstrated that a single injected drug-delivery system can reverse osteoarthritis in animals within weeks. The team, led by chemical and biological engineer Stephanie Bryant, reported success in early animal experiments. They aim to advance to human trials after further safety testing.