Osteoarthritis
Stem cell ‘pain sponge’ therapy shows promise for osteoarthritis relief and joint protection
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SereNeuro Therapeutics has reported promising preclinical data for SN101, an induced pluripotent stem cell-based therapy for chronic osteoarthritis pain. The treatment uses engineered peripheral pain-sensing neurons that sequester inflammatory pain factors without transmitting pain signals, while releasing regenerative molecules that may help preserve cartilage, according to data presented at an International Society for Stem Cell Research symposium.
Researchers at the University of Colorado Boulder have demonstrated that a single injected drug-delivery system can reverse osteoarthritis in animals within weeks. The team, led by chemical and biological engineer Stephanie Bryant, reported success in early animal experiments. They aim to advance to human trials after further safety testing.
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An umbrella review and pooled analysis published in BMJ’s open-access journal RMD Open concludes that exercise therapy—widely promoted as a first-line treatment for osteoarthritis—delivers, at most, small and short-term improvements in pain and function compared with placebo or no treatment, with benefits appearing smaller in larger and longer-term trials.