Osteoarthritis
Stem cell ‘pain sponge’ therapy shows promise for osteoarthritis relief and joint protection
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SereNeuro Therapeutics has reported promising preclinical data for SN101, an induced pluripotent stem cell-based therapy for chronic osteoarthritis pain. The treatment uses engineered peripheral pain-sensing neurons that sequester inflammatory pain factors without transmitting pain signals, while releasing regenerative molecules that may help preserve cartilage, according to data presented at an International Society for Stem Cell Research symposium.
Researchers at the University of Surrey have developed an AI system that predicts a patient's knee X-ray appearance one year ahead, aiding in osteoarthritis management. The tool generates visual forecasts and risk scores, presented at MICCAI 2025. It promises faster, more transparent predictions for better patient care.
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A Korean clinical trial has demonstrated that low-dose radiation therapy significantly reduces pain and improves mobility in patients with mild to moderate knee osteoarthritis, outperforming placebo effects. The treatment, which uses doses far below those for cancer, showed no side effects and could serve as an alternative to medications or surgery. Results were presented at the American Society for Radiation Oncology Annual Meeting.