Science
EPFL study links mitochondrial “pearling” to the even spacing of mtDNA nucleoids
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Scientists at EPFL report that a transient shape change in mitochondria—known as “pearling,” in which the organelle briefly forms bead-like constrictions—can redistribute clusters of mitochondrial DNA (mtDNA) into more evenly spaced nucleoids. The work, published April 2, 2026 in Science, suggests the process is triggered by calcium influx into mitochondria and may help explain how cells maintain robust mtDNA organization, a feature implicated in a range of mitochondrial-related disorders.
A 250-million-year-old fossil egg containing a Lystrosaurus embryo has provided the first direct evidence that mammal ancestors laid eggs. Discovered in South Africa, the find resolves a decades-old question about early mammalian reproduction following the End-Permian extinction. Researchers used advanced imaging to reveal the embryo's pre-hatching stage inside a soft-shelled egg.
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Researchers at the University of East Anglia have found that Seychelles warblers with closer social ties share more similar gut microbes, particularly anaerobic types spread through direct contact. The study on Cousin Island suggests social interactions drive this microbial exchange. Similar effects likely occur among humans living together.
Astronomers have detected Comet 41P/Tuttle-Giacobini-Kresák reversing its rotation direction, marking the first rapid such change observed in a celestial body. The 1-kilometer-wide comet slowed from a 20-hour spin in March 2017 to 46-60 hours two months later, then accelerated to about 14 hours by December. Researchers suggest outgassing from sublimating ice caused the reversal.
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Researchers at Israel's Weizmann Institute of Science have determined that genetics explain about 50% of differences in human lifespan, far more than previously estimated. The finding, published in the journal Science, challenges earlier views that placed genetic influence at 20-25% or less. By analyzing twin data and filtering out external death causes, the team uncovered this stronger hereditary role.
Chemists at the University of California, Riverside have stabilized a highly reactive carbene molecule in water, proving a 67-year-old hypothesis about vitamin B1's role in the body. The breakthrough, detailed in Science Advances, resolves a long-standing biochemical puzzle. It also suggests potential for greener chemical manufacturing.
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Researchers at the University of Colorado Boulder have demonstrated that a single injected drug-delivery system can reverse osteoarthritis in animals within weeks. The team, led by chemical and biological engineer Stephanie Bryant, reported success in early animal experiments. They aim to advance to human trials after further safety testing.
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