Hippocampus
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Researchers map four hidden neuron layers in hippocampal CA1 region
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Scientists at the Keck School of Medicine of the University of Southern California have identified a four-layer organization of neuron types in the mouse hippocampus’s CA1 region, a key hub for memory, navigation, and emotion. The study, published in Nature Communications in December 2025, uses advanced RNA imaging to chart genetic activity in tens of thousands of neurons and reveals shifting bands of specialized cells that may help explain behavioral differences and disease vulnerabilities.